Rare-Earth Na**crystals for Deeper Fluorescent Cancer Detection Na**particle-based tumor Detection schemes often rely on injecting particles that seek out and stick to Cancer cells. In order to see where they found their target, light, usually in the near-infrared range, is used to excite and fluoresce the na**particles. The limitation with this is that near-infrared light doesn’t penetrate soft tissue deep e**ugh to find tumor sites more than a few millimeters below the surface. Shortwave infrared, a spectrum of light invisible to the human eye having wavelengths between 0.9 and 1.7 microns, can transit through a lot more tissue before fading away, but the Fluorescent dyes that it is able to excite have either been too toxic or just don’t provide the image quality to accurately define the margins of tumors.
Researchers at Rutgers University are **w using Rare-Earth na**crystals, which are **t as rare as was commonly believed, to fluoresce to shortwave infrared. Since*rare-earths can still be toxic, the na**particles are surrounded by human serum albumin for safe passage through the body. These na**particles tend to collect around areas of disease and are excitable with shortwave infrared. Since different rare-earths glow at different colors when excited, using combinations of these metals can allow for wide-spectrum detectors of cancer. The researchers have shown that, at least in mice, they were able to spot Cancer earlier than using more traditional near-infrared or MR imaging.
10-27-2014, 09:13 PM
Rare-Earth Na**crystals for Deeper Fluorescent Cancer Detection
Na**particle-based tumor Detection schemes often rely on injecting particles that seek out and stick to Cancer cells. In order to see where they found their target, light, usually in the near-infrared range, is used to excite and fluoresce the na**particles. The limitation with this is that near-infrared light doesn’t penetrate soft tissue deep e**ugh to find tumor sites more than a few millimeters below the surface. Shortwave infrared, a spectrum of light invisible to the human eye having wavelengths between 0.9 and 1.7 microns, can transit through a lot more tissue before fading away, but the Fluorescent dyes that it is able to excite have either been too toxic or just don’t provide the image quality to accurately define the margins of tumors.
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