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08-05-2019, 06:47 PM
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3D Printed Cardiac Components
3D Printed Cardiac Components
 Researchersat Carnegie Mellon University have developed a method to 3D print collagen andcells to form organ components, potentially paving the way for full organprinting in the future. The technique, called Freeform Reversible Embedding ofSuspended Hydrogels (FRESH), involves printing collagen layer-by-layer in a bathof support gel, which allows it to solidify in the correct shape before use. 3D bioprinting has huge potential in creating organ replacements, for which there is an enormous demand. However, researchers have struggled to print organs or organ Components using appropriate materials, such as collagen and living cells. Current techniques result in bioprinted constructs that often lack the resolution and accuracy needed for implants. “Collagenis an extremely desirable biomaterial to 3D print with because it makes upliterally every single tissue in your body,” said Andrew Hudson, a researcherinvolved in the study. “What makes it so hard to 3D print, however, is that itstarts out as a fluid – so if you try to print this in air it just forms apuddle on your build platform. So, we’ve developed a technique that prevents itfrom deforming.” The FRESHtechnique involves printing the collagen into a bath containing a support gel.The gel supports the Printed collagen structure and helps it to solidify as itis Printed layer-by-layer. The technique allows large collagen structures to beprinted, potentially allowing for full organ printing in the future. The technique works with conventional 3D printers, meaning that almost anyone with access to such a printer could create these collagen scaffolds. Patient-specific implants may also be possible. So far, the research team has experimented with using MRI data to create patient-specific structures that could perfectly suit an individual patient. “What we’veshown is that we can print pieces of the heart out of cells and collagen intoparts that truly function, like a heart valve or a small beating ventricle,” saidAdam Feinberg, another researcher involved in the study. “By using MRI data ofa human heart, we were able to accurately reproduce patient-specific anatomicalstructure and 3D bioprint collagen and human heart cells.” See a videoabout the technique below. Study in Science:3Dbioprinting of collagen to rebuild components of the human heart Via: CarnegieMellon University 
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