While seemingly a myriad of polymer-based na**particles for targeted delivery of ***** have been created, it is still difficult to gauge how many actually*reach their final destination and deliver the cargo. Researchers at the Agency for Science, Tech**logy and Research (A*STAR) in Singapore have created a way of incorporating Quantum Dots into polymer na**particles to Allow for easy tracking of the na**particles within the body.
Quantum Dots are tiny crystals that can be created to reflect light at specific wavelengths. The researchers developed a way of using*poly(D,L-lactide-co-glycolide), or PLGA, as the encapsulating material to be able to either carry any of a number of different ***** or the specially*tuned Quantum dots. Using a mix of both, the researchers can inject the polymer na**particles and then use a laser to illuminate the target and measure how many are reaching the target from the returning fluorescence.
From the study abstract in journal Small:
The use of Quantum Dots enables efficient detection and precise quantitation of cellular uptake of particles which occupy 25% of the cell volume. The correlation of Quantum dot- and doxorubicin-incorporated na**particles is useful to develop an evaluation platform for Na**particle formulations through imaging and quantitation. This platform is also used to observe the surface properties effect of other polymers such as chitosan and poly(ethylene) glycol on the cellular interaction and uptake. Moreover, Quantum Dots can be used to study microparticle thera**stic delivery formulations by deliberately incorporating as visible ring surrounding the microparticles for their easy identifying and tracing in diag**stic and chemotherapeutic applications.
07-18-2015, 12:58 AM
Quantum Dots Allow Measurement of Therapeutic Na**particle ***********
Confocal images of Quantum Dots localized within colon cells.
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