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06-01-2015, 07:40 PM
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Shaping Implantable Medical Devices to Avoid Immune System
Shaping Implantable Medical Devices to Avoid Immune System
 Tiny Medical implants that can ferry *****, cells, or other therapies safely to sites of disease are already seeing the light of day.*Designing implantable*devices that are ig**red by the Immune System can be a challenge, so we usually rely on materials that are naturally biocompatible. At MIT, researchers have discovered that the size and shape of Implantable microparticles is also important as to whether the Immune System will attack them.  The team was developing Implantable capsules that can hold pancreatic islet cells as a potential therapy for Type 1 diabetes. It was important for the researchers to minimize the scarring around the implanted capsules, to allow them to interface with the perfusing blood and release insulin as needed. What investigators discovered is that spherical capsules 1.5 millimeter in diameter were functional months after implantation in diabetic mice, while those that are smaller, at .5 mm wide, were completely engulfed by scarring, preventing them from sensing blood sugar and releasing insulin. Similar results were achieved in **n-human primates. They also tested different shaped Devices made out of glass, polystyrene, stainless steel, and*polycaprolactone, a polyester, showing that the shape matters as well as the size.Study in Nature Materials: Size- and shape-dependent foreign body immune response to materials implanted in rodents and **n-human primates… Source: MIT… The post Shaping Implantable Medical Devices to Avoid Immune System appeared first on Medgadget. ??????? ??????: Shaping Implantable Medical Devices to Avoid Immune System || ??????: rss || ??????: اسم منتداك
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