Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots

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Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots

Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots
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Endovascular clot retrieval might become the standard future treatment for ischemic strokes, thanks to recent research published in the New England Journal of Medicine. While this option may be better than existing clot busting *****, researchers at the*Houston Methodist Research Institute have developed new Magnetic Na**particles that can deliver a high concentration of a drug directly to the clot site, dissolving it orders of magnitude faster than direct injections.

The Na**particles are made of iron oxide coated with albumin, which cloaks the Na**particles so that the immune system does **t immediately target them. Because the particles are magnetic, they are readily seen under MRI and can be steered using an external Magnetic guidance system. Moreover, the same magnet can induce a high frequency vibration of the na**particles, heating them up to further help with clot destruction.

The Na**particles have so far been tested in a laboratory environment involving mice and human blood, while the cargo ferried was the commonly used thrombolytic tPA (tissue plasmi**gen activator).

From the study abstract in*Advanced Functional Materials:

In vitro, as compared to free tPA, the proposed na**constructs demonstrate a 100-fold increase in dissolution rate, possibly because of a more intimate interaction of tPA with the fibrin network. The clot dissolution rate is further enhanced (10-fold) by mild, localized heating resulting from the exposure of tPA–NCs to AMF. Intravital microscopy experiments demonstrate Blood vessel reperfusion within a few minutes post tail vein injection of tPA–NCs. The proposed na**constructs also exhibit high transverse relaxivity (>400 × 10–3 m1 s1) for Magnetic resonance imaging. The multifunctional properties and the 3 orders of magnitude enhancement in clot dissolution make tPA–NCs a promising na**-thera**sis agent in thrombotic disease.

Study in Advanced Functional Materials: TPA Immobilization on Iron Oxide Na**cubes and Localized Magnetic Hyperthermia Accelerate Blood Clot Lysis…

Houston Methodist: Magnetic na**particles could stop blood clot-caused strokes…

The post Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots appeared first on Medgadget.

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