New Tissue Glue Can be Clearly Seen With X-Rays and Ultrasound

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New Tissue Glue Can be Clearly Seen With X-Rays and Ultrasound

New Tissue Glue Can be Clearly Seen With X-Rays and Ultrasound
Na**particles made With a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a Tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.


Researchers at Korea’s Institute for Basic Science and Seoul National University Hospital have designed and tested a Glue for binding tissues that also works as a contrast agent for X-rays, CTs, and Ultrasound imaging modalities. This is the first such Tissue Glue to have this set of properties, and, if approved for clinical applications,*may end up displacing other adhesives because it can be later easily monitored as to how it’s holding tissues together.

The material is made of na**particles that have tantalum oxide at their center, a radiopaque material, and a silica exterior that provides the gluing action.

Tested to exhibit less cellular toxicity than a combination of FDA approved cya**acrylate, a Tissue adhesive, and lipiodol, a radiopaque contrast agent (CA-Lp), the new material was successfully used to repair a damaged liver, and connect moving tissues of the lung and limbs in laboratory animals. Its radiopaque properties were similar to lipiodol and it was about as visible as cya**acrylate under X-rays.

Na**particles made With a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a Tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.


From Institute for Basic Science:

CA-Lp tends to trigger immune reaction within 3 days from the operation and inflammation after 14-65 days, while experiments showed that TSN did **t show such adverse effects after 56 days.

TSNs also ensured accurate target localization during movement; when TSNs were injected in rat’s thigh and calf muscles, they did **t move even during the flexion and extension of the leg. “TSNs are well fixed to tissues so that na**particles and tissues move in unison.

Here’s a quick video demonstrating the new Glue under X-rays:



Study in Nature Communications: Multifunctional na**particles as a tissue adhesive and an injectable marker for image-guided procedures…

Via: Institute for Basic Science…

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