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04-07-2016, 07:30 PM
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Drug Ferrying Na**particles Report Back While Killing Cancer Cells
[IMG]http://www.medgadget.com/wp-content/uploads/2016/04/chemo-na**particle.jpg[/IMG] Cancer therapies have a pernicious way of being effective only for a subset of people suffering from a particular manifestation of the disease. Because there’s ** way to k**w whether a treatment is working until long after it has begun, patients on chemo too often suffer from a medicine that does them ** good. **w researchers at Brigham and Women’s Hospital in Boston have developed a “reporter na**particle” that is able to ferry medication and then detect cell death around itself to***tify clinicians whether the therapy it delivered is working. Reporting in the Proceedings of the National Academy of Sciences, the researchers describe a particle that reacts to the presence of activated*caspase enzyme by emitting a green fluorescence. Caspase is activated in quantity during cellular death, so a bright glow produced by the Na**particles is indicative that nearby Cells are dying. Since the Na**particles can be made to target specific tumor Cells thanks to attached antibodies, the Cells that die will be predominantly Cancer cells. The team tested the tech**logy using both the chemo drug*paclitaxel, as well as the*anti-PD-L1 immu**therapy agent, demonstrating that the tech**logy works with both types of therapy. From the study abstract: The reporter Na**particles are engineered from a **vel two-staged stimuli-responsive polymeric material with an optimal ratio of an enzyme-cleavable Drug or immu**therapy (effector elements) and a Drug function-activatable reporter element. The spatiotemporally constrained delivery of the effector and the reporter elements in a single na**particle produces maximum signal enhancement due to the availability of the reporter element in the same cell as the drug, thereby effectively capturing the temporal apoptosis process. Using chemotherapy-sensitive and chemotherapy-resistant tumors in vivo, we show that the reporter Na**particles can provide a real-time **ninvasive readout of tumor response to chemotherapy. The reporter na**particle can also monitor the efficacy of immune checkpoint inhibition in mela**ma. The self-reporting capability, for the first time to our k**wledge, captures an anticancer na**particle in action in vivo.Study in PNAS: Reporter na**particle that monitors its anticancer efficacy in real time… Source: Brigham and Women’s… The post Drug Ferrying Na**particles Report Back While Killing Cancer Cells appeared first on Medgadget. ??????? ??????: Drug Ferrying Na**particles Report Back While Killing Cancer Cells || ??????: rss || ??????: اسم منتداك
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