At **rth Carolina State University and the University of **rth Carolina at Chapel Hill researchers have*created *****es layered with microneedles to deliver cancer Immu**therapy right Into the skin where Mela**ma has been detected. The *****es deliver anti-PD-1 antibodies that prevent the cancer from confusing T cells Into ig**ring the tumor. Previously, the antibodies have been tried through injections, but **t e**ugh reach the cancer cells while potentially causing side effects throughout the body. The antibodies are placed within na**particles which are then loaded within the microneedles along with glucose oxidase. When the *****es are applied to cancer sites, the blood enters the needles, the glucose reacts with glucose oxidase producing acid that breaks up the na**particles. This allows anti-PD-1 to be released in a controlled manner right Into the tumor.
The researchers have already tested the *****es on mice with mela**ma, showing that the *****es worked better than injecting anti-PD-1 Directly Into the blood stream.
03-24-2016, 11:27 PM
Microneedle ***** Releases Immu**therapy Directly Into Mela**ma Tumors
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