Skin
***** Detects Multiple Protein Biomarkers for
Blood-Free Disease Detection
Cryogenic scanning electron microscopy micrograph of a microprojection array inserted in mouse skin. Epidermal (E) and dermal (D) layers are indicated and separated by a dashed line. This technique allows to visualize the array applied to the
Skin in situ. Simon Corrie, University of Queensland
Blood draws are often the first step in diag**sing*all kinds of diseases, but many people, especially kids, just can’t stand the process. Moreover, taking blood samples requires having trained staff performing the procedure, often a rare commodity, especially in underdeveloped nations. A team of Australian researchers headed by Simon R. Corrie of the University of Queensland, have developed a
Skin ***** that may be coming to a nurse near you as a friendlier option for taking blood samples for
Disease diag**sis.
Previously, *****es that penetrate the
Skin and detect a unique biomarker have been developed, but they have limited use and can’t often provide a confirmed diag**sis. The new
***** is able to test for two
Protein Biomarkers at the same time, and in lab tests with malarial mice it was able to detect*recombinant
P. falciparum r
PfHRP2 and total IgG, both
Biomarkers for the disease.*The microneedles within the
***** penetrate into the*intradermal layer of the
Skin and have antibodies for the target
Biomarkers attached to them. The
Biomarkers naturally adhere to the antibodies, which can be detected to confirm their presence in the intradermal fluid.
The researchers in their study conclude that “such devices can be used to capture clinically relevant, circulating
Protein Biomarkers of infectious
Disease via the skin, with potential applications as a minimally invasive and lab-free biomarker
Detection platform.”
Study in
Analytical Chemistry:*
Capture of the Circulating Plasmodium falciparum Biomarker HRP2 in a Multiplexed Format, via a Wearable Skin *****…
ACS:*
Skin ***** could replace the syringe for disease diag**sis…
