Dynamic
Magnetic Field Activates Na**particles to
Force Tumor Cells to
Self-Destruct (VIDEO)
[IMG]http://cdn.medgadget.com/wp-content/uploads/2014/04/magnetically-controlled-cancer-na**particles.jpg[/IMG]
Magnetically activated
Na**particles have been researched as a tool for killing tumors in the past, but generally the mechanism of action was using a
Magnetic Field to resonate and heat up the
Na**particles and so kill the neoplasm. This can expose nearby healthy tissue to dangerous levels of heat, especially when the
Na**particles miss their cancer target. Researchers at Lund University in Sweden just reported in journal
ACS Na** on a new method of using superparamagnetic *iron oxide
Na**particles to coerce the
Tumor Cells to kill themselves.
The team developed a special
Magnetic Field generator that is able to spin the
Na**particles instead of making them vibrate. They attached a
Tumor seeking antibody to the
Na**particles and delivered them to
Tumor cells. Once inside, the
Magnetic Field was activated to
Force the
Na**particles to turn back and forth, causing lysosomal membranes within the cell to break and release their payload. Since lysosomes contain everything necessary to break down biomolecules that make up the cell, the cancer cell dies from within while **t causing any damage to nearby tissues.
Some details from the study abstract:
…we covalently conjugated SPIONs with antibodies targeting the lysosomal protein marker LAMP1 (LAMP1-SPION). Remote activation of slow rotation of LAMP1-SPIONs significantly improved the efficacy of cellular internalization of the na**particles. LAMP1-SPIONs then preferentially accumulated along the membrane in lysosomes in both rat insuli**ma Tumor Cells and human pancreatic beta Cells due to binding of LAMP1-SPIONs to endoge**us LAMP1. Further activation of torques by the LAMP1-SPIONs bound to lysosomes resulted in rapid decrease in size and number of lysosomes, attributable to tearing of the lysosomal membrane by the shear Force of the rotationally activated LAMP1-SPIONs. This remote activation resulted in an increased expression of early and late apoptotic markers and impaired cell growth.
Study in
ACS Na**:
Dynamic Magnetic Fields Remote-Control Apoptosis via Na**particle Rotation…
Lund University:*
NA**PARTICLES CAUSE CANCER CELLS TO SELF-DESTRUCT…
