Scaffolds Covered in Stem Cells and Silver Ions to Prevent Osteomyelitis
 

Scaffolds Covered in Stem Cells and Silver Ions to Prevent Osteomyelitis
http://www.medgadget.com/wp-content/...rix-seeded.jpg Bone infections are often very difficult to treat, and with the rise of MRSA this issue has become only more challenging.آ*A team of researchers fromآ*University of Missouri,آ*University of **rth Carolina at Chapel Hill and **rth Carolina State University, and Silpakorn University in Thailand has developed a way of making tissue scaffolds that ward off MRSA while promoting natural healing at the site of their implantation.

http://www.medgadget.com/wp-content/...a-scaffold.jpgThis microscopic image shows silver-coated, stem cell-seeded scaffolds after MRSA bacteria were introduced. These medical devices can help health care providers fight MRSA while growing lost bone tissue. Credit: Mahsa Mohiti-Asli, NC State University


The structure of the scaffold is made of polylactic acid (PLA), a polymer commonly used in implants. It is bioresorbable and is ******* by the body over time. Over the structure a coating of silver ion is applied and stem cellsآ*ready to differentiate into bone are added.

The silver ions, already widely used to ward off infections in a variety of medical applications, prevent MRSA from settling in, while the stem cells turn to bone. The PLA structure and silver eventually disappear, leaving **thing but natural tissue.

All this is still relegated to the laboratory and is yet to be tried in animal models. Nevertheless, the proof-of-principle points to one day hip implant patients first donating some of their own cells before the surgery to prepare for the operation.

Here’s a University of Missouri video with more about the research:



Study in journal Tissue Engineering Part A:آ*Evaluation of Silver Ion-Releasing Scaffolds in a 3D Coculture System of MRSA and Human Adipose-Derived Stem Cells for Their Potential Use in Treatment or Prevention of Osteomyelitis…

Via:آ*University of Missouri…

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