New Class of Drug Ferrying Na**particles May Overcome Limitations of Existing Systems
 

New Class of Drug Ferrying Na**particles May Overcome Limitations of Existing Systems
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Russian scientists at the Lomo**sov Moscow State University are reporting the development of new drug ferrying na**-capsules that work fundamentally differently than existing na**particles. Each capsule consists of two concentric polymer shells that swell at different temperatures. The outer shell protects the capsule and also prevents the capsules from sticking to one a**ther when they’re releasing their cargo, a problem that has confounded researchers for a while. The inner shell has pores that grow larger as it swells in size, allowing the release of compounds within.

Building the structure was difficult and involved using a silica core around which the shells were created and then the core dissolved to create an empty space.

More from Lomo**sov Moscow State University:

At this stage, the work was purely fundamental and was intended primarily to demonstrate the effectiveness of the concept. Experiments were carried out in the temperature range of 32-42°C. It is slightly more than the temperature range favorable for a human, although in the future this range can be easily narrowed, states Igor Potemkin.

The scientific collaboration is going to be prolonged for a**ther four years. ‘There are still many questions,’ the scientist says. ‘For example, we have “caught” a structure in which a cavity does **t collapse as the pores are closed. **w we need to understandwhy it happens, how does the density of the layers’ crosslink effect, i.e., what is the minimum amount of crosslinker that does **t lead to a collapse of the cavity, and so on. ”

Potemkin is sure that in any case the created na**-containers are the ideal carriers for targeted drug delivery. Moreover, their synthesis is neither complex **r really expensive. Although at current stage of research it is difficult to pro**unce the precise cost, the collaboration’s plans already include the creation of the large-scale,commercially acceptable production of na**gels.

Study in Scientific Reports: Multi-Shell Hollow Na**gels with Responsive Shell Permeability…

Source: Lomo**sov Moscow State University…

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