**vel Na**tower Electrodes for Deep Tissue Intracellular Recordings
 

**vel Na**tower Electrodes for Deep Tissue Intracellular Recordings
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Electrophysiology is an invaluable technique for studying the electrical activity of neurons in the brain and has important clinical applications. The use of na**wire and na**tube intracellular electrode recording devices has improved the spatial resolution and sensitivity of electrophysiological techniques. However, intracellular recordings within thick tissues is limited by the length of the na**tube/na**wire electrode, which has insufficient stiffness at lengths greater than 10 µm. As a result, existing na**devices can**t be used to record neuronal electrical activity within thick tissue slices ex vivo or within deep tissue structures in vivo.

To overcome this challenge, researchers at Toyohashi University of Tech**logy in Japan have developed a long na**scale-tipped microneedle electrode.* The 120 µm-long “na**tower” electrode is sufficiently strong to penetrate thicker and deeper tissue structures, overcoming the limitations of conventional na**tube and na**wire electrodes.* The development of this device, described in an article published in Small, diversifies the scope of preclinical and clinical applications of na**electrodes in electrophysiology.

Study in Small: Na**scale-Tipped High-Aspect-Ratio Vertical Microneedle Electrodes for Intracellular Recordings

Via:*Toyohashi University of Tech**logy

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