Automated Chemist: A Molecule-Making Machine Creates New Compounds
 

Automated Chemist: A Molecule-Making Machine Creates New Compounds
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Chemists designing new compounds have to do a lot of simulating and predicting before a new molecule is developed. This is a slow and meticulous process, but **w a new machine developed at the University of Illi**is, Urbana-Champaign is able to synthesize small molecules completely automatically. In effect, it allows chemists to draw a new molecule and have the machine put it together without any assistance.

The machine works by bringing together multiple pre-made molecular blocks that can predictably snap together. Blocks are delivered one at a time using a mechanism that washes away any excess reagents before the next step is taken. This has already led to the development of more than a dozen different classes of ***** and the potential exists for making many thousands more.

Martin D. Burke, M.D., Ph.D, the lead scientist on the project, has recently*started REVOLUTION Medicines, a company that will commercialize the tech**logy. Here he is talking about the new molecule-making machine:





Here’s a snippet from the study abstract in Science:

Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block–based synthesis platform to include even Csp3-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are **w accessible with this platform.

Study in Science: Synthesis of many different types of organic small molecules using one automated process…

Related press release: Third Rock Ventures Launches REVOLUTION Medicines with $45 Million ****** A to Redesign Evolution’s Products to Treat Serious Diseases…

Source: University of Illi**is…

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