Ultrasound and Microbubbles Seemingly Treat Alzheimer’s in Mice
 

Ultrasound and Microbubbles Seemingly Treat Alzheimer’s in Mice
http://www.medgadget.com/wp-content/...alzheimers.jpgMicrobubbles injected into the blood vibrate under ultrasound, temporarily forcing cells lining the blood-brain barrier apart. This may allow amyloid-fighting antibodies to slip into brain tissue (shown) or rouse cells that clean up the protein.


Ultrasound combined with microbubbles has been a promising new way of penetrating the blood-brain barrier (see flashbacks below). Once microbubbles are injected, an ultrasound probe is pointed toward the treatment site. As microbubbles pass through the ultrasound beam, they vibrate and deform in different ways, pushing on cells within the blood-brain barrier. This pushing and shoving seems to open up temporary passages in the barrier, allowing ***** to be pushed through that would otherwise have a next to zero*chance of reaching the brain. In a new development,*researchers **w are finally showing that this technique may work in allowing*neurological conditions to be treated with existing and future ***** that are naturally blocked by the blood-brain barrier.

The team from The University of Queensland in Australia have successfully ******* amyloid plaque from the brain and restored memory in a mouse model of Alzheimer’s disease. They injected the mice with the microbubbles and swept the ultrasound beam across the entire brain. The treatment was repeated almost daily. After these treatments the mice were put through three memory intensive tasks. Compared to the control group that received microbubbles but ** ultrasound, the mice showed “full restoration of memory in all three tasks,” according to the researchers. The next step is to try this out in clinical trials. We hope these results can be replicated and brought to practice as soon as possible.

Some details from the study abstract in Science Translational Medicine:

Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of A into the lysosomes of activated microglia in mouse brains subjected to SUS, with ** concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the **vel object recognition test, and the active place avoidance task.

Flashbacks:*Temporarily Opening Up the Blood-Brain Barrier Using Ultrasound Waves…;*Microbubbles Help Ultrasound See Blood Vasculature Like Never Before…;***n-Invasive Brain Acoustic Drug Delivery…;*Blood-Brain Barrier Opened With Ultrasound Implants to Let ***** Through…

Study in Science Translational Medicine: Scanning ultrasound removes amyloid- and restores memory in an Alzheimer’s disease mouse model…

More from Science/AAAS News:*Ultrasound therapies target brain cancers and Alzheimer’s disease…

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