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11-18-2014, 10:31 PM
Dual-Imaging Contrast Agents Work Under MRI, Near-Infrared
http://cdn.medgadget.com/wp-content/uploads/2014/11/Dual-Imaging.jpg
Contrast agents are used in medicine to*help visualize things*that certain imaging modalities, such as MR or CT, can**t resolve on their own. Typically, each modality has its own imaging agents that don’t help when switching to a**ther imaging system.*To help overcome this limitation, researchers at MIT developed na**particles that, depending on the situation, either fluoresce or*are visible under MRI.
The particles are a new variety of so-called branched-bottlebrush polymer dual-modality organic radical contrast agents. They are nitroxide radical-based na**structures that are excitable by near-infrared light and are readily identified under MRI. The team used the particles to follow the path of vitamin C spreading throughout the bodies of mice. High levels of vitamin C make the particles hard to see under MRI, but they’re readily apparent when illuminated with near-infrared. The opposite holds true at lower concentrations of vitamin C, so MRI is used to track it in that instance.
Study in Nature Communications:*Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging… (http://www.nature.com/ncomms/2014/141118/ncomms6460/full/ncomms6460.html)
More from MIT:*Na**particles that enable both MRI and fluorescent imaging could monitor cancer, other diseases…. (http://news******.mit.edu/2014/na**particles-mri-fluorescent-imaging-monitor-cancer-1118)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=yuGhVGI5TV4:pAyQr2ltIcI:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/yuGhVGI5TV4
http://cdn.medgadget.com/wp-content/uploads/2014/11/Dual-Imaging.jpg
Contrast agents are used in medicine to*help visualize things*that certain imaging modalities, such as MR or CT, can**t resolve on their own. Typically, each modality has its own imaging agents that don’t help when switching to a**ther imaging system.*To help overcome this limitation, researchers at MIT developed na**particles that, depending on the situation, either fluoresce or*are visible under MRI.
The particles are a new variety of so-called branched-bottlebrush polymer dual-modality organic radical contrast agents. They are nitroxide radical-based na**structures that are excitable by near-infrared light and are readily identified under MRI. The team used the particles to follow the path of vitamin C spreading throughout the bodies of mice. High levels of vitamin C make the particles hard to see under MRI, but they’re readily apparent when illuminated with near-infrared. The opposite holds true at lower concentrations of vitamin C, so MRI is used to track it in that instance.
Study in Nature Communications:*Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging… (http://www.nature.com/ncomms/2014/141118/ncomms6460/full/ncomms6460.html)
More from MIT:*Na**particles that enable both MRI and fluorescent imaging could monitor cancer, other diseases…. (http://news******.mit.edu/2014/na**particles-mri-fluorescent-imaging-monitor-cancer-1118)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=yuGhVGI5TV4:pAyQr2ltIcI:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=yuGhVGI5TV4:pAyQr2ltIcI:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/yuGhVGI5TV4