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11-03-2014, 11:24 PM
Laboratory Blood Vessel to Study How Cancers Spread
http://cdn.medgadget.com/wp-content/uploads/2014/11/artificial-blood-vessel.png
The mechanisms by which cancers metastasize and propagate throughout the body remain mostly a mystery. Primary tumors can be found and *******, but all too frequently the cancers randomly recur to fight a**ther fight. To better understand how cancer cells break off and travel through the blood stream to colonize other parts of the body, researchers at Johns Hopkins University created a transparent artificial blood vessel in which cancer behavior can be studied close-up.
The vessel is coated with collagen and seeded with endothelial cells. Once the device is ready, a clump of breast tumor tissue tagged with fluorescent markers is placed just outside the collagen matrix. Using a microscope, the markers can be tracked as the cancer cells move through the artificial vessel wall to reach the blood flow within the lumen.
The Johns Hopkins Institute for Na**BioTech**logy released a podcast about this research which you can listen to*here… (http://inbt.jhu.edu/audio/andrew-wong8-25-FINAL_01.mp3)
Johns Hopkins:*Artificial blood vessel visualizes cancer cell journey… (http://inbt.jhu.edu/2014/10/17/artificial-blood-vessel-visualizes-cancer-cell-journey/)
Study in journal Cancer Research:*Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform… (http://cancerres.aacrjournals.org/content/74/17/4937.abstract?sid=a99e79cd-c7f4-47e5-bf6f-8142e1e6f584)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=Ug4b1kb_pxE:o6o6vOh2bBI:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/Ug4b1kb_pxE
http://cdn.medgadget.com/wp-content/uploads/2014/11/artificial-blood-vessel.png
The mechanisms by which cancers metastasize and propagate throughout the body remain mostly a mystery. Primary tumors can be found and *******, but all too frequently the cancers randomly recur to fight a**ther fight. To better understand how cancer cells break off and travel through the blood stream to colonize other parts of the body, researchers at Johns Hopkins University created a transparent artificial blood vessel in which cancer behavior can be studied close-up.
The vessel is coated with collagen and seeded with endothelial cells. Once the device is ready, a clump of breast tumor tissue tagged with fluorescent markers is placed just outside the collagen matrix. Using a microscope, the markers can be tracked as the cancer cells move through the artificial vessel wall to reach the blood flow within the lumen.
The Johns Hopkins Institute for Na**BioTech**logy released a podcast about this research which you can listen to*here… (http://inbt.jhu.edu/audio/andrew-wong8-25-FINAL_01.mp3)
Johns Hopkins:*Artificial blood vessel visualizes cancer cell journey… (http://inbt.jhu.edu/2014/10/17/artificial-blood-vessel-visualizes-cancer-cell-journey/)
Study in journal Cancer Research:*Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform… (http://cancerres.aacrjournals.org/content/74/17/4937.abstract?sid=a99e79cd-c7f4-47e5-bf6f-8142e1e6f584)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=Ug4b1kb_pxE:o6o6vOh2bBI:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=Ug4b1kb_pxE:o6o6vOh2bBI:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/Ug4b1kb_pxE