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10-24-2014, 12:11 AM
Bioinspired Blood and Bacteria Repellent Coating for Medical Devices (VIDEO)
http://cdn.medgadget.com/wp-content/uploads/2014/10/tlp-coating.pngThese glass slides were dipped in blood to demonstrate the effectiveness of the TLP coating. While blood sticks to the untreated slide on the left, the TLP-treated slide on the right emerges entirely clear. (Credit: Harvard’s Wyss Institute)
As Don Ingber, M.D., Ph.D., Founding Director of Harvard’s Wyss Institute stated, “Devising a way to prevent blood clotting without using anticoagulants is one of the holy grails in medicine.”*Even devices that have*been properly analyzed and engineered to serve their*purpose can run into problems once implanted into the body. Cardiac implants like mechanical heart valves and other medical devices come into contact with flowing blood. This can cause a multitude of problems such as blood clotting and*bacterial infection.
To solve this problem, researchers at Wyss took already FDA approved materials and combined them to form a coating that repels both blood and bacteria. Originally, the idea for this coating came from Professor Amy Smith Berylson and her Slippery Liquid-Infused Porous Surfaces (SLIPS) system, a concept inspired by the carnivorous pitcher plant. The coating is created in a two-step surface-coating process. Coined Tethered-Liquid Perfluorocarbon (TLP), the process is performed*by adding a mo**layer of perfluorocarbon*and then a layer of liquid perfluorocarbon.
This material has already been tested*in vivo*where the team implanted tubing and catheters with this coating into blood vessels of pigs. The results showed ** blood clots for at least eight hours. Furthermore, when the bacteria*Pseudomonas aerugi**sa*was cultured on a coated medical tube, only one in a billion bacteria adhered to the tube.*The scientists even demonstrated*that*the mighty gecko could **t stick to surfaces coated with TLP.
More from from the Wyss Institute: Bioinspired coating for medical devices repels blood and bacteria… (http://wyss.harvard.edu/viewpressrelease/171/bioinspired-coating-for-medical-devices-repels-blood-and-bacteria)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=Sj5Ve3qbOlg:5VsmzQh7vL8:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/Sj5Ve3qbOlg
http://cdn.medgadget.com/wp-content/uploads/2014/10/tlp-coating.pngThese glass slides were dipped in blood to demonstrate the effectiveness of the TLP coating. While blood sticks to the untreated slide on the left, the TLP-treated slide on the right emerges entirely clear. (Credit: Harvard’s Wyss Institute)
As Don Ingber, M.D., Ph.D., Founding Director of Harvard’s Wyss Institute stated, “Devising a way to prevent blood clotting without using anticoagulants is one of the holy grails in medicine.”*Even devices that have*been properly analyzed and engineered to serve their*purpose can run into problems once implanted into the body. Cardiac implants like mechanical heart valves and other medical devices come into contact with flowing blood. This can cause a multitude of problems such as blood clotting and*bacterial infection.
To solve this problem, researchers at Wyss took already FDA approved materials and combined them to form a coating that repels both blood and bacteria. Originally, the idea for this coating came from Professor Amy Smith Berylson and her Slippery Liquid-Infused Porous Surfaces (SLIPS) system, a concept inspired by the carnivorous pitcher plant. The coating is created in a two-step surface-coating process. Coined Tethered-Liquid Perfluorocarbon (TLP), the process is performed*by adding a mo**layer of perfluorocarbon*and then a layer of liquid perfluorocarbon.
This material has already been tested*in vivo*where the team implanted tubing and catheters with this coating into blood vessels of pigs. The results showed ** blood clots for at least eight hours. Furthermore, when the bacteria*Pseudomonas aerugi**sa*was cultured on a coated medical tube, only one in a billion bacteria adhered to the tube.*The scientists even demonstrated*that*the mighty gecko could **t stick to surfaces coated with TLP.
More from from the Wyss Institute: Bioinspired coating for medical devices repels blood and bacteria… (http://wyss.harvard.edu/viewpressrelease/171/bioinspired-coating-for-medical-devices-repels-blood-and-bacteria)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=Sj5Ve3qbOlg:5VsmzQh7vL8:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=Sj5Ve3qbOlg:5VsmzQh7vL8:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/Sj5Ve3qbOlg