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07-20-2017, 10:29 PM
New Tissue Glue Can be Clearly Seen With X-Rays and Ultrasound
https://www.medgadget.com/wp-content/uploads/2017/07/radiopaque-glue.jpgNa**particles made with a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.
Researchers at Korea’s Institute for Basic Science and Seoul National University Hospital have designed and tested a glue for binding tissues that also works as a contrast agent for X-rays, CTs, and ultrasound imaging modalities. This is the first such tissue glue to have this set of properties, and, if approved for clinical applications,*may end up displacing other adhesives because it can be later easily monitored as to how it’s holding tissues together.
The material is made of na**particles that have tantalum oxide at their center, a radiopaque material, and a silica exterior that provides the gluing action.
Tested to exhibit less cellular toxicity than a combination of FDA approved cya**acrylate, a tissue adhesive, and lipiodol, a radiopaque contrast agent (CA-Lp), the new material was successfully used to repair a damaged liver, and connect moving tissues of the lung and limbs in laboratory animals. Its radiopaque properties were similar to lipiodol and it was about as visible as cya**acrylate under X-rays.
https://www.medgadget.com/wp-content/uploads/2017/07/the-glue.jpgNa**particles made with a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.
From Institute for Basic Science:
CA-Lp tends to trigger immune reaction within 3 days from the operation and inflammation after 14-65 days, while experiments showed that TSN did **t show such adverse effects after 56 days.
TSNs also ensured accurate target localization during movement; when TSNs were injected in rat’s thigh and calf muscles, they did **t move even during the flexion and extension of the leg. “TSNs are well fixed to tissues so that na**particles and tissues move in unison.
Here’s a quick video demonstrating the new glue under X-rays:
Study in Nature Communications: Multifunctional na**particles as a tissue adhesive and an injectable marker for image-guided procedures… (https://www.nature.com/articles/ncomms15807)
Via: Institute for Basic Science… (http://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=14737)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=gNIKTY1kOTA:Fat05ZHXMp8:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/gNIKTY1kOTA
https://www.medgadget.com/wp-content/uploads/2017/07/radiopaque-glue.jpgNa**particles made with a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.
Researchers at Korea’s Institute for Basic Science and Seoul National University Hospital have designed and tested a glue for binding tissues that also works as a contrast agent for X-rays, CTs, and ultrasound imaging modalities. This is the first such tissue glue to have this set of properties, and, if approved for clinical applications,*may end up displacing other adhesives because it can be later easily monitored as to how it’s holding tissues together.
The material is made of na**particles that have tantalum oxide at their center, a radiopaque material, and a silica exterior that provides the gluing action.
Tested to exhibit less cellular toxicity than a combination of FDA approved cya**acrylate, a tissue adhesive, and lipiodol, a radiopaque contrast agent (CA-Lp), the new material was successfully used to repair a damaged liver, and connect moving tissues of the lung and limbs in laboratory animals. Its radiopaque properties were similar to lipiodol and it was about as visible as cya**acrylate under X-rays.
https://www.medgadget.com/wp-content/uploads/2017/07/the-glue.jpgNa**particles made with a shell of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx) are used to make a tissue adhesive and visible to ultrasound, X-ray, and fluorescent imaging.
From Institute for Basic Science:
CA-Lp tends to trigger immune reaction within 3 days from the operation and inflammation after 14-65 days, while experiments showed that TSN did **t show such adverse effects after 56 days.
TSNs also ensured accurate target localization during movement; when TSNs were injected in rat’s thigh and calf muscles, they did **t move even during the flexion and extension of the leg. “TSNs are well fixed to tissues so that na**particles and tissues move in unison.
Here’s a quick video demonstrating the new glue under X-rays:
Study in Nature Communications: Multifunctional na**particles as a tissue adhesive and an injectable marker for image-guided procedures… (https://www.nature.com/articles/ncomms15807)
Via: Institute for Basic Science… (http://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=14737)
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=gNIKTY1kOTA:Fat05ZHXMp8:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=gNIKTY1kOTA:Fat05ZHXMp8:gIN9vFwOqvQ)
http://feeds.feedburner.com/~r/Medgadget/~4/gNIKTY1kOTA