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06-28-2017, 03:40 AM
Georgia Tech Researchers May Have Developed Tech**logy to Prevent Cancer Metastasis
https://www.medgadget.com/wp-content/uploads/2017/06/gold-na**rods-action-300x100.jpghttps://www.medgadget.com/wp-content/uploads/2017/06/gold-na**rods-action.jpg
https://www.medgadget.com/wp-content/uploads/2017/06/gold_na**rods.jpgGold na**rodsآ*Credit: Georgia Tech / El-Sayed group
Cancer cells rely on their cytoskeletonsآ*to move away from where they are born, resulting in metastasis of the cancer. This process has been a challenge to prevent, but doing so can go a long way toward successfully killing cancers before they’re allowed to spread.
Researchers at Georgia Tech are **w reporting inآ*Proceedings of the National Academy of Sciences on anآ*approach they’ve developed that inhibits the functionality of cytoskeletons and, at least in a laboratory study, prevents cancer cells from migrating away from their original tumor.
Cytoskeletons can create octopus-like tentacles that extend from the cell’s body and which produce cell motion allowing cancer cells to move around. The Georgia Tech team was able to designآ*Argâ??Glyâ??Asp (RGD) peptide-functionalized gold na**rods that they managed to target to attach to integrin, a protein involved in the development of cytoskeletons. Once the na**rods were connected to the proteins, the team then used a low energy near infrared laser to heat up the na**rods, damaging the integrins. Because the effect is extremely localized, nearby cells were **t affected, yet the ability to move around was seriously hindered by the technique.
So far this was only tried on cancer cells outside the body and in a very controlled environment. Translating this technique into a clinical application will require more challenges to overcome, yet the current research is pointing to an exciting potential for controlling cancer.
Top image:آ*From left to right: Untreated lab culture cancer cell, lab culture cancer cell with gold na**rods attached, lab culture cancer cell after addition of gentle NIR laser light.آ*Credit: Georgia Tech / El-Sayed group
Study in Proceedings of the National Academy of Sciences: Targeting cancer cell integrins using gold na**rods in photothermal therapy inhibits migration through affecting cytoskeletal proteins… (http://www.pnas.org/content/early/2017/06/21/1703151114)
Via: Georgia Tech… (http://www.news.gatech.edu/2017/06/26/thwarting-metastasis-breaking-cancers-legs-gold-rods)
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https://www.medgadget.com/wp-content/uploads/2017/06/gold-na**rods-action-300x100.jpghttps://www.medgadget.com/wp-content/uploads/2017/06/gold-na**rods-action.jpg
https://www.medgadget.com/wp-content/uploads/2017/06/gold_na**rods.jpgGold na**rodsآ*Credit: Georgia Tech / El-Sayed group
Cancer cells rely on their cytoskeletonsآ*to move away from where they are born, resulting in metastasis of the cancer. This process has been a challenge to prevent, but doing so can go a long way toward successfully killing cancers before they’re allowed to spread.
Researchers at Georgia Tech are **w reporting inآ*Proceedings of the National Academy of Sciences on anآ*approach they’ve developed that inhibits the functionality of cytoskeletons and, at least in a laboratory study, prevents cancer cells from migrating away from their original tumor.
Cytoskeletons can create octopus-like tentacles that extend from the cell’s body and which produce cell motion allowing cancer cells to move around. The Georgia Tech team was able to designآ*Argâ??Glyâ??Asp (RGD) peptide-functionalized gold na**rods that they managed to target to attach to integrin, a protein involved in the development of cytoskeletons. Once the na**rods were connected to the proteins, the team then used a low energy near infrared laser to heat up the na**rods, damaging the integrins. Because the effect is extremely localized, nearby cells were **t affected, yet the ability to move around was seriously hindered by the technique.
So far this was only tried on cancer cells outside the body and in a very controlled environment. Translating this technique into a clinical application will require more challenges to overcome, yet the current research is pointing to an exciting potential for controlling cancer.
Top image:آ*From left to right: Untreated lab culture cancer cell, lab culture cancer cell with gold na**rods attached, lab culture cancer cell after addition of gentle NIR laser light.آ*Credit: Georgia Tech / El-Sayed group
Study in Proceedings of the National Academy of Sciences: Targeting cancer cell integrins using gold na**rods in photothermal therapy inhibits migration through affecting cytoskeletal proteins… (http://www.pnas.org/content/early/2017/06/21/1703151114)
Via: Georgia Tech… (http://www.news.gatech.edu/2017/06/26/thwarting-metastasis-breaking-cancers-legs-gold-rods)
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