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01-11-2017, 05:25 PM
Na**discs Train Immune System to Attack and Kill Tumors
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Immu**therapy has great great potential for fighting cancer, but controlling it is difficult. At University of Michigan investigators have developed an approach that uses specially designed na**discs to train the immune system to attack tumors. The na**discs, made of synthetic high density lipoproteins, contain neoantigens, particles*which trigger an immune response, of a specific tumor. These are delivered into the body to train immune system T-cells to attack that type of cancer and prevent its recurrence.
The researchers, reporting in journal Nature Materials, tested the new tech**logy on mice suffering from mela**ma and colon cancers. They showed that a full 27% of T-cells in the mice got to work fighting the tumors after the introduction of the na**discs. The team also coupled the therapy with techniques already used to amplify T-cell activity, achieving complete tumor reduction within ten days in nearly all the mice. To evaluate long term benefits of the na**discs, ten weeks after the initial treatment they injected the healed mice with cells from their former tumors. The immune system immediately responded and swiftly killed the cancer cells.
Study in Nature Materials:*Designer vaccine na**discs for personalized cancer immu**therapy… (http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat4822.html)
Via:*University of Michigan… (http://ns.umich.edu/new/releases/24438-na**discs-deliver-personalized-cancer-therapy-to-immune-system)
This post Na**discs Train Immune System to Attack and Kill Tumors (http://www.medgadget.com/2017/01/na**discs-train-immune-system-attack-kill-tumors.html) appeared first on Medgadget (http://www.medgadget.com).
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http://www.medgadget.com/wp-content/uploads/2017/01/na**discs-cancer-therapy.jpg
Immu**therapy has great great potential for fighting cancer, but controlling it is difficult. At University of Michigan investigators have developed an approach that uses specially designed na**discs to train the immune system to attack tumors. The na**discs, made of synthetic high density lipoproteins, contain neoantigens, particles*which trigger an immune response, of a specific tumor. These are delivered into the body to train immune system T-cells to attack that type of cancer and prevent its recurrence.
The researchers, reporting in journal Nature Materials, tested the new tech**logy on mice suffering from mela**ma and colon cancers. They showed that a full 27% of T-cells in the mice got to work fighting the tumors after the introduction of the na**discs. The team also coupled the therapy with techniques already used to amplify T-cell activity, achieving complete tumor reduction within ten days in nearly all the mice. To evaluate long term benefits of the na**discs, ten weeks after the initial treatment they injected the healed mice with cells from their former tumors. The immune system immediately responded and swiftly killed the cancer cells.
Study in Nature Materials:*Designer vaccine na**discs for personalized cancer immu**therapy… (http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat4822.html)
Via:*University of Michigan… (http://ns.umich.edu/new/releases/24438-na**discs-deliver-personalized-cancer-therapy-to-immune-system)
This post Na**discs Train Immune System to Attack and Kill Tumors (http://www.medgadget.com/2017/01/na**discs-train-immune-system-attack-kill-tumors.html) appeared first on Medgadget (http://www.medgadget.com).
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