ahlam1399
08-18-2016, 02:20 PM
BOSTON: Pregnant women on anti-psychotic ***** can continue taking most of those medications without worrying the pills will increase the risk of their newborns having birth defects, a new study suggests.
"We did **t see a meaningful increase in risk for any of the ***** with the exception of risperidone," said lead author Krista Huybrechts, of Brigham and Women’s Hospital and Harvard Medical School in Boston.
Women taking the anti-psychotic risperidone were about 26 percent more likely than women **t taking anti-psychotic ***** to give birth to children with birth defects, the researchers report in JAMA Psychiatry.
There is ** biological reason risperidone would increase the risk of birth defects while others don't, Huybrechts said, adding that the finding is a safety signal that should be investigated.
"It definitely needs more study," she said. "We did a lot of analyses to see if we could explain that observation and we couldn't."
Because of concerns surrounding the unk**wn effects of experimental ***** on women and fetuses, researchers have traditionally excluded pregnant women from clinical trials. That exclusion has led to a lack of information about the safety of some ***** during pregnancy, Huybrechts' team writes.
For the new study, the researchers used data on over 1.36 million U.S. pregnant women enrolled between 2000 and 2010 in Medicaid, the government-run insurance program for the poor.
The researchers attempted to match women who were similar to each other, except for taking anti-psychotic medications. Then they looked to see if the newborns of women taking anti-psychotics were more likely to be diag**sed with a birth defect in the first 90 days of life than the children of women **t using the *****.
The researchers also looked for differences between outcomes depending on which of the two main types of anti-psychotics women used. So-called typical anti-psychotics work by similar mechanisms to one a**ther, but the second-generation atypical anti-psychotics act differently from their predecessors.
About 33 of 1,000 children **t exposed to anti-psychotics in the womb were diag**sed with birth defects. That compared to about 38 per 1,000 children exposed to typical anti-psychotics and about 45 children per 1,000 who were exposed to atypical anti-psychotics.
But after adjusting the numbers to account for other factors that may increase the risk of birth defects, the researchers found ** increased risk for either type of anti-psychotic drug - with the exception of risperidone.
Dr. Katherine Wisner, who co-wrote an editorial accompanying the new research, said the amount of data and the methods used make this a "landmark" study.
"For women taking other medications besides risperidone, it is really solid data to show there is ** identifiable increased risk of birth defects," said Wisner, of the **rthwestern University Feinberg School of Medicine in Chicago.
Huybrechts cautioned that people should **t draw the conclusion that anti-psychotics are completely safe during pregnancy. The research team only looked at birth defects, which is one potential outcome during pregnancy.
The team has plans to evaluate anti-psychotic use for the risk of gestational diabetes and other pregnancy related outcomes, she said.
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أكثر... (http://feedproxy.google.com/~r/com/YEor/~3/X_g0Cx1nxUw/143439-Most-antipsychotic-*****-**t-tied-to-birth-defects)
"We did **t see a meaningful increase in risk for any of the ***** with the exception of risperidone," said lead author Krista Huybrechts, of Brigham and Women’s Hospital and Harvard Medical School in Boston.
Women taking the anti-psychotic risperidone were about 26 percent more likely than women **t taking anti-psychotic ***** to give birth to children with birth defects, the researchers report in JAMA Psychiatry.
There is ** biological reason risperidone would increase the risk of birth defects while others don't, Huybrechts said, adding that the finding is a safety signal that should be investigated.
"It definitely needs more study," she said. "We did a lot of analyses to see if we could explain that observation and we couldn't."
Because of concerns surrounding the unk**wn effects of experimental ***** on women and fetuses, researchers have traditionally excluded pregnant women from clinical trials. That exclusion has led to a lack of information about the safety of some ***** during pregnancy, Huybrechts' team writes.
For the new study, the researchers used data on over 1.36 million U.S. pregnant women enrolled between 2000 and 2010 in Medicaid, the government-run insurance program for the poor.
The researchers attempted to match women who were similar to each other, except for taking anti-psychotic medications. Then they looked to see if the newborns of women taking anti-psychotics were more likely to be diag**sed with a birth defect in the first 90 days of life than the children of women **t using the *****.
The researchers also looked for differences between outcomes depending on which of the two main types of anti-psychotics women used. So-called typical anti-psychotics work by similar mechanisms to one a**ther, but the second-generation atypical anti-psychotics act differently from their predecessors.
About 33 of 1,000 children **t exposed to anti-psychotics in the womb were diag**sed with birth defects. That compared to about 38 per 1,000 children exposed to typical anti-psychotics and about 45 children per 1,000 who were exposed to atypical anti-psychotics.
But after adjusting the numbers to account for other factors that may increase the risk of birth defects, the researchers found ** increased risk for either type of anti-psychotic drug - with the exception of risperidone.
Dr. Katherine Wisner, who co-wrote an editorial accompanying the new research, said the amount of data and the methods used make this a "landmark" study.
"For women taking other medications besides risperidone, it is really solid data to show there is ** identifiable increased risk of birth defects," said Wisner, of the **rthwestern University Feinberg School of Medicine in Chicago.
Huybrechts cautioned that people should **t draw the conclusion that anti-psychotics are completely safe during pregnancy. The research team only looked at birth defects, which is one potential outcome during pregnancy.
The team has plans to evaluate anti-psychotic use for the risk of gestational diabetes and other pregnancy related outcomes, she said.
http://feeds.feedburner.com/~r/com/YEor/~4/X_g0Cx1nxUw
أكثر... (http://feedproxy.google.com/~r/com/YEor/~3/X_g0Cx1nxUw/143439-Most-antipsychotic-*****-**t-tied-to-birth-defects)