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03-24-2016, 10:27 PM
Microneedle ***** Releases Immu**therapy Directly Into Mela**ma Tumors
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At **rth Carolina State University and the University of **rth Carolina at Chapel Hill researchers have*created *****es layered with microneedles to deliver cancer immu**therapy right into the skin where mela**ma has been detected. The *****es deliver anti-PD-1 antibodies that prevent the cancer from confusing T cells into ig**ring the tumor. Previously, the antibodies have been tried through injections, but **t e**ugh reach the cancer cells while potentially causing side effects throughout the body. The antibodies are placed within na**particles which are then loaded within the microneedles along with glucose oxidase. When the *****es are applied to cancer sites, the blood enters the needles, the glucose reacts with glucose oxidase producing acid that breaks up the na**particles. This allows anti-PD-1 to be released in a controlled manner right into the tumor.
The researchers have already tested the *****es on mice with mela**ma, showing that the *****es worked better than injecting anti-PD-1 directly into the blood stream.
Study in NA** Letters: Enhanced Cancer Immu**therapy by Microneedle *****-Assisted Delivery of Anti-PD1 Antibody… (http://pubs.acs.org/doi/abs/10.1021/acs.na**lett.5b05030)
Via:***rth Carolina… (https://news.ncsu.edu/2016/03/gu-immune-needle-2016/)
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At **rth Carolina State University and the University of **rth Carolina at Chapel Hill researchers have*created *****es layered with microneedles to deliver cancer immu**therapy right into the skin where mela**ma has been detected. The *****es deliver anti-PD-1 antibodies that prevent the cancer from confusing T cells into ig**ring the tumor. Previously, the antibodies have been tried through injections, but **t e**ugh reach the cancer cells while potentially causing side effects throughout the body. The antibodies are placed within na**particles which are then loaded within the microneedles along with glucose oxidase. When the *****es are applied to cancer sites, the blood enters the needles, the glucose reacts with glucose oxidase producing acid that breaks up the na**particles. This allows anti-PD-1 to be released in a controlled manner right into the tumor.
The researchers have already tested the *****es on mice with mela**ma, showing that the *****es worked better than injecting anti-PD-1 directly into the blood stream.
Study in NA** Letters: Enhanced Cancer Immu**therapy by Microneedle *****-Assisted Delivery of Anti-PD1 Antibody… (http://pubs.acs.org/doi/abs/10.1021/acs.na**lett.5b05030)
Via:***rth Carolina… (https://news.ncsu.edu/2016/03/gu-immune-needle-2016/)
The post Microneedle ***** Releases Immu**therapy Directly Into Mela**ma Tumors (http://www.medgadget.com/2016/03/microneedle-*****-releases-immu**therapy-directly-into-mela**ma-tumors.html) appeared first on Medgadget (http://www.medgadget.com).
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