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02-07-2016, 04:59 PM
Shells of Hepatitis E Virus to Deliver ***** to Kill Cancer, Treat Other Diseases
http://www.medgadget.com/wp-content/uploads/2016/02/virus-particles.png
At UC Davis scientists managed to use the hollow shells of Hepatitis E virus as transport vehicles to deliver *****. The viral*shell was selected because the Hepatitis E virus is able to travel through the digestive system without being destroyed, and so would be a good candidate for PO formulations.
The viral shells are made of Hep. E proteins and do **t contain any DNA, denying any possibility of viral infection.
The research team tested the particles by applying*cysteine ami** acids that let*molecules called LXY-30 be attached in turn to them. These LXY-30 molecules hone in on breast cancer cells and the researchers showed using a fluorescent marker that the virus-like shells were able to gather right on breast cancer tumors in lab mice.
Some details from the study abstract:
Five surface-exposed residues were mutated to cysteine to allow conjugation to maleimide-linked chemical groups via thiol-selective linkages. Engineered virus-like na**particles were then covalently conjugated to a breast cancer recognized ligand, LXY30 and an amine-coupled near-infrared fluorescence dye.
LXY30-HEV VLP was checked for its binding and entry to a breast cancer cell line and for tumor targeting in vivo to breast cancer tissue in mice. The engineered virus-like na**particle **t only targeted cancer cells, but also appeared immune silent to native hepatitis E virus antibodies due to epitope disruption at the antibody-binding site.
Study in journal*Na**medicine: Chemically activatable viral capsid functionalized for cancer targeting… (http://www.futuremedicine.com/doi/10.2217/nnm.15.207)
Source: UC Davis… (http://blogs.ucdavis.edu/egghead/2016/02/03/hepatitis-virus-like-particles-as-potential-cancer-treatment/)
The post Shells of Hepatitis E Virus to Deliver ***** to Kill Cancer, Treat Other Diseases (http://www.medgadget.com/2016/02/shells-of-hepatitis-e-virus-to-deliver-*****-to-kill-cancer-treat-other-diseases.html) appeared first on Medgadget (http://www.medgadget.com).
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http://www.medgadget.com/wp-content/uploads/2016/02/virus-particles.png
At UC Davis scientists managed to use the hollow shells of Hepatitis E virus as transport vehicles to deliver *****. The viral*shell was selected because the Hepatitis E virus is able to travel through the digestive system without being destroyed, and so would be a good candidate for PO formulations.
The viral shells are made of Hep. E proteins and do **t contain any DNA, denying any possibility of viral infection.
The research team tested the particles by applying*cysteine ami** acids that let*molecules called LXY-30 be attached in turn to them. These LXY-30 molecules hone in on breast cancer cells and the researchers showed using a fluorescent marker that the virus-like shells were able to gather right on breast cancer tumors in lab mice.
Some details from the study abstract:
Five surface-exposed residues were mutated to cysteine to allow conjugation to maleimide-linked chemical groups via thiol-selective linkages. Engineered virus-like na**particles were then covalently conjugated to a breast cancer recognized ligand, LXY30 and an amine-coupled near-infrared fluorescence dye.
LXY30-HEV VLP was checked for its binding and entry to a breast cancer cell line and for tumor targeting in vivo to breast cancer tissue in mice. The engineered virus-like na**particle **t only targeted cancer cells, but also appeared immune silent to native hepatitis E virus antibodies due to epitope disruption at the antibody-binding site.
Study in journal*Na**medicine: Chemically activatable viral capsid functionalized for cancer targeting… (http://www.futuremedicine.com/doi/10.2217/nnm.15.207)
Source: UC Davis… (http://blogs.ucdavis.edu/egghead/2016/02/03/hepatitis-virus-like-particles-as-potential-cancer-treatment/)
The post Shells of Hepatitis E Virus to Deliver ***** to Kill Cancer, Treat Other Diseases (http://www.medgadget.com/2016/02/shells-of-hepatitis-e-virus-to-deliver-*****-to-kill-cancer-treat-other-diseases.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=ThA-sHEz2cE:JbPgZfYT4EU:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=ThA-sHEz2cE:JbPgZfYT4EU:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=ThA-sHEz2cE:JbPgZfYT4EU:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=ThA-sHEz2cE:JbPgZfYT4EU:gIN9vFwOqvQ)
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