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06-23-2015, 12:16 AM
Researchers Unveil Surface Sampling Probe for Intraoperative Biopsies
http://cdn.medgadget.com/wp-content/uploads/2015/06/probe.png
The Oak Ridge National Laboratory, k**wn best for nuclear ******* research, has developed a surface sampling probe that may replace professional pathologists in identifying cancerous tissue during surgeries. Currently, samples are taken to the pathology lab to confirm that all of the cancer has been *******. This takes considerable time, extended by the preparation process necessary before the pathologist looks into the microscope. The new probe hopes to do the same, but right inside the operating room and without requiring a pathologist to operate.
The device uses a droplet-based mass spectrometry technique that is able to spot even large biomolecules such as proteins, a capability other mass spectrometry methods have **t been able to achieve. So far the device has been able to identify ***** and certain metabolites in animal tissue, hopefully soon moving on to trials with human samples.
Some details from the study abstract:
Described here are the results from the profiling of the proteins arginine vasopressin (AVP) and adre**corticotropic hormone (ACTH) from **rmal human pituitary gland and pituitary ade**ma tissue sections, using a fully automated droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS system for spatially resolved sampling, HPLC separation, and mass spectrometric detection. Excellent correlation was found between the protein distribution data obtained with this method and data obtained with matrix-assisted laser desorption/ionization (MALDI) chemical imaging analyses of ****** sections of the same tissue. The protein distributions correlated with the visible anatomic pattern of the pituitary gland. AVP was most abundant in the posterior pituitary gland region (neurohypophysis), and ATCH was dominant in the anterior pituitary gland region (ade**hypophysis). The relative amounts of AVP and ACTH sampled from a ****** of ACTH-secreting and **n-secreting pituitary ade**mas correlated with histopathological evaluation.
Study in journal*Analytical and Bioanalytical Chemistry: Profiling of adre**corticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS… (http://link.springer.com/article/10.1007/s00216-015-8803-2)
Source: Oak Ridge National Laboratory… (http://www.ornl.gov/ornl/news/news-releases/2015/new-tool-on-horizon-for-surgeons-treating-cancer-patients)
The post Researchers Unveil Surface Sampling Probe for Intraoperative Biopsies (http://www.medgadget.com/2015/06/researchers-unveil-surface-sampling-probe-intraoperative-biopsies.html) appeared first on Medgadget (http://www.medgadget.com).
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http://cdn.medgadget.com/wp-content/uploads/2015/06/probe.png
The Oak Ridge National Laboratory, k**wn best for nuclear ******* research, has developed a surface sampling probe that may replace professional pathologists in identifying cancerous tissue during surgeries. Currently, samples are taken to the pathology lab to confirm that all of the cancer has been *******. This takes considerable time, extended by the preparation process necessary before the pathologist looks into the microscope. The new probe hopes to do the same, but right inside the operating room and without requiring a pathologist to operate.
The device uses a droplet-based mass spectrometry technique that is able to spot even large biomolecules such as proteins, a capability other mass spectrometry methods have **t been able to achieve. So far the device has been able to identify ***** and certain metabolites in animal tissue, hopefully soon moving on to trials with human samples.
Some details from the study abstract:
Described here are the results from the profiling of the proteins arginine vasopressin (AVP) and adre**corticotropic hormone (ACTH) from **rmal human pituitary gland and pituitary ade**ma tissue sections, using a fully automated droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS system for spatially resolved sampling, HPLC separation, and mass spectrometric detection. Excellent correlation was found between the protein distribution data obtained with this method and data obtained with matrix-assisted laser desorption/ionization (MALDI) chemical imaging analyses of ****** sections of the same tissue. The protein distributions correlated with the visible anatomic pattern of the pituitary gland. AVP was most abundant in the posterior pituitary gland region (neurohypophysis), and ATCH was dominant in the anterior pituitary gland region (ade**hypophysis). The relative amounts of AVP and ACTH sampled from a ****** of ACTH-secreting and **n-secreting pituitary ade**mas correlated with histopathological evaluation.
Study in journal*Analytical and Bioanalytical Chemistry: Profiling of adre**corticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS… (http://link.springer.com/article/10.1007/s00216-015-8803-2)
Source: Oak Ridge National Laboratory… (http://www.ornl.gov/ornl/news/news-releases/2015/new-tool-on-horizon-for-surgeons-treating-cancer-patients)
The post Researchers Unveil Surface Sampling Probe for Intraoperative Biopsies (http://www.medgadget.com/2015/06/researchers-unveil-surface-sampling-probe-intraoperative-biopsies.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=Tz7NFAdXY9g:qYtb7L5f2Ag:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=Tz7NFAdXY9g:qYtb7L5f2Ag:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=Tz7NFAdXY9g:qYtb7L5f2Ag:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=Tz7NFAdXY9g:qYtb7L5f2Ag:gIN9vFwOqvQ)
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