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06-11-2015, 08:03 PM
Polymeric Na**particles to Make Sure Cancers Don’t Recur
http://cdn.medgadget.com/wp-content/uploads/2015/06/na**particles-against-cancer-stem-cells.png
While chemotherapy may be highly effective at eliminating a tumor, there are often cancer stem-like cells that survive and begin forming a new tumor. That’s because these cells are typically more resistant to chemo. Researchers at*Ohio State University have **w developed a new na**particle designed to specifically attack these tumor reinitiating cells to prevent the cancer from coming back.
The polymeric na**particles are coated with chitosan, specifically targeting a receptor on the cancer stem-like cells. A large dose of doxorubicin, a common chemo drug, is encapsulated within the na**particles. In order to release the poiso**us compound at the right place, the na**particles were designed to break open when inside an acidic environment of*the type that exists inside of tumors.
The team tested the new na**particles on mice with human breast tumors, showing that the technique increases the cytotoxicity of doxorubicin by six times when killing cancer stem-like cells, while shrinking the rest of the tumor with ** **ticeable side effects on the animals.
Study in ACS Na**: Chitosan-Decorated Doxorubicin-Encapsulated Na**particle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells… (http://pubs.acs.org/doi/abs/10.1021/nn506928p)
More from American Chemical Society… (http://www.acs.org/content/acs/en.html)
The post Polymeric Na**particles to Make Sure Cancers Don’t Recur (http://www.medgadget.com/2015/06/polymeric-na**particles-to-make-sure-cancers-dont-recur.html) appeared first on Medgadget (http://www.medgadget.com).
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http://cdn.medgadget.com/wp-content/uploads/2015/06/na**particles-against-cancer-stem-cells.png
While chemotherapy may be highly effective at eliminating a tumor, there are often cancer stem-like cells that survive and begin forming a new tumor. That’s because these cells are typically more resistant to chemo. Researchers at*Ohio State University have **w developed a new na**particle designed to specifically attack these tumor reinitiating cells to prevent the cancer from coming back.
The polymeric na**particles are coated with chitosan, specifically targeting a receptor on the cancer stem-like cells. A large dose of doxorubicin, a common chemo drug, is encapsulated within the na**particles. In order to release the poiso**us compound at the right place, the na**particles were designed to break open when inside an acidic environment of*the type that exists inside of tumors.
The team tested the new na**particles on mice with human breast tumors, showing that the technique increases the cytotoxicity of doxorubicin by six times when killing cancer stem-like cells, while shrinking the rest of the tumor with ** **ticeable side effects on the animals.
Study in ACS Na**: Chitosan-Decorated Doxorubicin-Encapsulated Na**particle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells… (http://pubs.acs.org/doi/abs/10.1021/nn506928p)
More from American Chemical Society… (http://www.acs.org/content/acs/en.html)
The post Polymeric Na**particles to Make Sure Cancers Don’t Recur (http://www.medgadget.com/2015/06/polymeric-na**particles-to-make-sure-cancers-dont-recur.html) appeared first on Medgadget (http://www.medgadget.com).
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