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05-07-2015, 12:53 AM
BreathID May Offer Biopsy-free Screening for **n-*******ic Steatohepatitis
http://cdn.medgadget.com/wp-content/uploads/2015/05/BreathID.jpg
Exalenz Bioscience (Modiin, Israel) just an**unced that its BreathID test system is starting a trial to gauge whether it can be used to diag**se **n-*******ic steatohepatitis (NASH). The disease causes the buildup of fat in the liver, as well as inflammation and fibrosis, often leading to liver failure. Right **w the only way to diag**se it is through a liver biopsy, so a simple breath test can be of great benefit for diag**sing NASH.
The study will involve 200 patients and will compare the BreathID urea breath test to biopsies, pathological exams, and blood testing. One of the goals of the clinical trial will be to tune the device to best detect NASH so that BreathID can be used on larger patient populations while providing consistent results. Previously, the BreathID tech**logy has been shown to detect the presence of*Helicobacter pylori through*exhaled breath, the cause of many peptic ulcers.
“Diag**sing NASH is of paramount clinical importance as it identifies patients at risk of progression and those in need of pharmacotherapy,” said Prof. Vlad Ratziu, MD, Universite Pierre et Marie Curie Hospital and head of Hepatology at Hospital La Pitié-Salpêtrière, Paris, France. “However, it has been extremely challenging using traditional **n-invasive methods based on serum biomarkers or liver imaging. The current study aims to assess a new, and in**vative diag**stic test to fulfill this major unmet clinical need within a comprehensive grading and staging of the disease.”
Flashbacks:*BreathID Hp **n-Invasively Test Spots H. Pylori in Exhaled Breath… (http://www.medgadget.com/2013/07/breathid-hp-**n-invasively-test-spots-h-pylori-in-exhaled-breath.html);*Let’s Smell Your H. pylori! BreathID Racks Up New Positive Trial on Road to FDA Approval… (http://www.medgadget.com/2009/12/lets_smell_your_h_pylori_breathid_racks_up_new_pos itive_trial_on_road_to_fda_approval.html);*BreathI D for Simple Liver Disease Identification Gets FDA’s Trial OK… (http://www.medgadget.com/2008/07/breathid_for_simple_liver_disease_identification_g ets_fdas_ok.html);
Exalenz Bioscience homepage… (http://www.exalenz.com/)
Source: Exalenz Bioscience… (http://www.prnewswire.com/news-releases/exalenz-bioscience-launches-additional-clinical-study-of-breath-based-diag**stic-test-addressing-the-2-billion-nash-market-potential-300078199.html)
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http://cdn.medgadget.com/wp-content/uploads/2015/05/BreathID.jpg
Exalenz Bioscience (Modiin, Israel) just an**unced that its BreathID test system is starting a trial to gauge whether it can be used to diag**se **n-*******ic steatohepatitis (NASH). The disease causes the buildup of fat in the liver, as well as inflammation and fibrosis, often leading to liver failure. Right **w the only way to diag**se it is through a liver biopsy, so a simple breath test can be of great benefit for diag**sing NASH.
The study will involve 200 patients and will compare the BreathID urea breath test to biopsies, pathological exams, and blood testing. One of the goals of the clinical trial will be to tune the device to best detect NASH so that BreathID can be used on larger patient populations while providing consistent results. Previously, the BreathID tech**logy has been shown to detect the presence of*Helicobacter pylori through*exhaled breath, the cause of many peptic ulcers.
“Diag**sing NASH is of paramount clinical importance as it identifies patients at risk of progression and those in need of pharmacotherapy,” said Prof. Vlad Ratziu, MD, Universite Pierre et Marie Curie Hospital and head of Hepatology at Hospital La Pitié-Salpêtrière, Paris, France. “However, it has been extremely challenging using traditional **n-invasive methods based on serum biomarkers or liver imaging. The current study aims to assess a new, and in**vative diag**stic test to fulfill this major unmet clinical need within a comprehensive grading and staging of the disease.”
Flashbacks:*BreathID Hp **n-Invasively Test Spots H. Pylori in Exhaled Breath… (http://www.medgadget.com/2013/07/breathid-hp-**n-invasively-test-spots-h-pylori-in-exhaled-breath.html);*Let’s Smell Your H. pylori! BreathID Racks Up New Positive Trial on Road to FDA Approval… (http://www.medgadget.com/2009/12/lets_smell_your_h_pylori_breathid_racks_up_new_pos itive_trial_on_road_to_fda_approval.html);*BreathI D for Simple Liver Disease Identification Gets FDA’s Trial OK… (http://www.medgadget.com/2008/07/breathid_for_simple_liver_disease_identification_g ets_fdas_ok.html);
Exalenz Bioscience homepage… (http://www.exalenz.com/)
Source: Exalenz Bioscience… (http://www.prnewswire.com/news-releases/exalenz-bioscience-launches-additional-clinical-study-of-breath-based-diag**stic-test-addressing-the-2-billion-nash-market-potential-300078199.html)
The post BreathID May Offer Biopsy-free Screening for **n-*******ic Steatohepatitis (http://www.medgadget.com/2015/05/breathid-may-offer-biopsy-free-screening-for-**n-*******ic-steatohepatitis.html) appeared first on Medgadget (http://www.medgadget.com).
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