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04-20-2015, 10:12 PM
Hemostatic Na**particles Packed with Steroids Help Control Internal Bleeding After Explosive Blasts
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Explosions are the primary way American soldiers get injured on the battlefield these days. Internal bleeding within the lungs is particularly dangerous and requires immediate care, but the time it takes before an injured soldier reaches a military hospital is often too long for survival. Researchers at Virginia Tech and Case Western Reserve University have developed special na**particles that can be systemically injected into a patient right after a blast injury to help with internal clot formation and to reduce inflammation within the lungs.
http://www.medgadget.com/wp-content/uploads/2015/04/medevac.jpgCredit: Army Medicine (https://www.flickr.com/photos/armymedicine/14805422936)
The*hemostatic dexamethasone na**particles (hDNP) were loaded with*corticosteroid and injected into laboratory rats subjected to trauma. They showed that compared to the control group, the rats that received the new therapy had much higher blood oxygen levels while having less internal bleeding and cellular tissue damage.
From the study abstract:
In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone na**particles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immu**histochemistry. We found that dexamethasone-loaded hemostatic na**particles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.
Article in ACS Macro Letters: Steroid-Loaded Hemostatic Na**particles Combat Lung Injury after Blast Trauma… (http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00061)
Source: ACS… (https://www.acs.org/content/acs/en/pressroom/presspacs/2015/acs-presspac-april-15-2015/**vel-na**particles-could-save-soldiers-lives-after-explosions.html)
The post Hemostatic Na**particles Packed with Steroids Help Control Internal Bleeding After Explosive Blasts (http://www.medgadget.com/2015/04/hemostatic-na**particles-packed-with-steroids-help-control-internal-bleeding-after-explosive-blasts.html) appeared first on Medgadget (http://www.medgadget.com).
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http://www.medgadget.com/wp-content/uploads/2015/04/steroid-loaded-na**particles.jpg
Explosions are the primary way American soldiers get injured on the battlefield these days. Internal bleeding within the lungs is particularly dangerous and requires immediate care, but the time it takes before an injured soldier reaches a military hospital is often too long for survival. Researchers at Virginia Tech and Case Western Reserve University have developed special na**particles that can be systemically injected into a patient right after a blast injury to help with internal clot formation and to reduce inflammation within the lungs.
http://www.medgadget.com/wp-content/uploads/2015/04/medevac.jpgCredit: Army Medicine (https://www.flickr.com/photos/armymedicine/14805422936)
The*hemostatic dexamethasone na**particles (hDNP) were loaded with*corticosteroid and injected into laboratory rats subjected to trauma. They showed that compared to the control group, the rats that received the new therapy had much higher blood oxygen levels while having less internal bleeding and cellular tissue damage.
From the study abstract:
In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone na**particles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immu**histochemistry. We found that dexamethasone-loaded hemostatic na**particles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.
Article in ACS Macro Letters: Steroid-Loaded Hemostatic Na**particles Combat Lung Injury after Blast Trauma… (http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00061)
Source: ACS… (https://www.acs.org/content/acs/en/pressroom/presspacs/2015/acs-presspac-april-15-2015/**vel-na**particles-could-save-soldiers-lives-after-explosions.html)
The post Hemostatic Na**particles Packed with Steroids Help Control Internal Bleeding After Explosive Blasts (http://www.medgadget.com/2015/04/hemostatic-na**particles-packed-with-steroids-help-control-internal-bleeding-after-explosive-blasts.html) appeared first on Medgadget (http://www.medgadget.com).
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