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03-13-2015, 02:57 AM
Automated Chemist: A Molecule-Making Machine Creates New Compounds
http://www.medgadget.com/wp-content/uploads/2015/03/molecule-making-machine.jpg
Chemists designing new compounds have to do a lot of simulating and predicting before a new molecule is developed. This is a slow and meticulous process, but **w a new machine developed at the University of Illi**is, Urbana-Champaign is able to synthesize small molecules completely automatically. In effect, it allows chemists to draw a new molecule and have the machine put it together without any assistance.
The machine works by bringing together multiple pre-made molecular blocks that can predictably snap together. Blocks are delivered one at a time using a mechanism that washes away any excess reagents before the next step is taken. This has already led to the development of more than a dozen different classes of ***** and the potential exists for making many thousands more.
Martin D. Burke, M.D., Ph.D, the lead scientist on the project, has recently*started REVOLUTION Medicines, a company that will commercialize the tech**logy. Here he is talking about the new molecule-making machine:
Here’s a snippet from the study abstract in Science:
Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block–based synthesis platform to include even Csp3-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are **w accessible with this platform.
Study in Science: Synthesis of many different types of organic small molecules using one automated process… (http://www.sciencemag.org/content/347/6227/1221)
Related press release: Third Rock Ventures Launches REVOLUTION Medicines with $45 Million ****** A to Redesign Evolution’s Products to Treat Serious Diseases… (http://revolutionmedicines.com/docs/RevMed-******-A-Final-2.4.15.pdf)
Source: University of Illi**is… (http://news.illi**is.edu/news/15/0312molecule_machine_MartyBurke.html)
The post Automated Chemist: A Molecule-Making Machine Creates New Compounds (http://www.medgadget.com/2015/03/automated-chemist-a-molecule-making-machine-creates-new-compounds.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=lLEQnQPb54o:ZpjdS3bAo4I:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:gIN9vFwOqvQ)
https://hameed.nwar.uk/vb//feeds.feedburner.com/~r/Medgadget/~4/lLEQnQPb54o
http://www.medgadget.com/wp-content/uploads/2015/03/molecule-making-machine.jpg
Chemists designing new compounds have to do a lot of simulating and predicting before a new molecule is developed. This is a slow and meticulous process, but **w a new machine developed at the University of Illi**is, Urbana-Champaign is able to synthesize small molecules completely automatically. In effect, it allows chemists to draw a new molecule and have the machine put it together without any assistance.
The machine works by bringing together multiple pre-made molecular blocks that can predictably snap together. Blocks are delivered one at a time using a mechanism that washes away any excess reagents before the next step is taken. This has already led to the development of more than a dozen different classes of ***** and the potential exists for making many thousands more.
Martin D. Burke, M.D., Ph.D, the lead scientist on the project, has recently*started REVOLUTION Medicines, a company that will commercialize the tech**logy. Here he is talking about the new molecule-making machine:
Here’s a snippet from the study abstract in Science:
Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block–based synthesis platform to include even Csp3-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are **w accessible with this platform.
Study in Science: Synthesis of many different types of organic small molecules using one automated process… (http://www.sciencemag.org/content/347/6227/1221)
Related press release: Third Rock Ventures Launches REVOLUTION Medicines with $45 Million ****** A to Redesign Evolution’s Products to Treat Serious Diseases… (http://revolutionmedicines.com/docs/RevMed-******-A-Final-2.4.15.pdf)
Source: University of Illi**is… (http://news.illi**is.edu/news/15/0312molecule_machine_MartyBurke.html)
The post Automated Chemist: A Molecule-Making Machine Creates New Compounds (http://www.medgadget.com/2015/03/automated-chemist-a-molecule-making-machine-creates-new-compounds.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=lLEQnQPb54o:ZpjdS3bAo4I:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=lLEQnQPb54o:ZpjdS3bAo4I:gIN9vFwOqvQ)
https://hameed.nwar.uk/vb//feeds.feedburner.com/~r/Medgadget/~4/lLEQnQPb54o