rss
03-12-2015, 04:20 AM
Injectable Polymer Helps Stop Severe Bleeding
http://www.medgadget.com/wp-content/uploads/2015/03/blood-clot.jpgA 3-D rendering of fibrin forming a blood clot, with PolySTAT (in blue) binding strands together. William Walker/University of Washington
There are new*tech**logies (http://www.medgadget.com/2014/09/revmedx-gunshot-hemostasis-system-and-tourniquet-belt-at-tedmed-2014-video.html) out there that can help stop bleeding from gunshot wounds, a new approach may help deliver hemostasis on a microscopic scale. Researchers at the University of Washington have developed a new polymer that, when injected, rapidly works to help develop a solid clot.
The PolySTAT material works by fusing fibrin strands to each other and creating links between the clumps. This creates a strong web of fibrin capable of withstanding pressure from blood pressing against the clot. Importantly, the material is **t influenced by fibri**lytic enzymes that break up fibrin strands to begin the healing process. While the enzymes are important in the long run, they slow down clot formation, a dangerous activity during acute bleeding. Moreover, the material continues to work even when levels of a protein used to make fibrin drop.
In a pre-clinical study using lab rats, the researchers showed a 100% success rate in stopping bleeding to an otherwise lethal injury to the femoral artery. For*comparison, rats that were treated with albumin had only a 20% survival.
http://www.medgadget.com/wp-content/uploads/2015/03/fibrin-cross-linking.jpgBlood clots treated with PolySTAT (second from right) had denser fibrin networks, which helps reinforce and strengthen the clots. University of Washington
Study in Science Translational Medicine: A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis… (http://stm.sciencemag.org/content/7/277/277ra29)
Source: University of Washington… (http://www.washington.edu/news/2015/03/10/an-injectable-uw-polymer-could-keep-soldiers-trauma-patients-from-bleeding-to-death/)
The post Injectable Polymer Helps Stop Severe Bleeding (http://www.medgadget.com/2015/03/injectable-polymer-helps-stop-severe-bleeding.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=MRfpCZ2oraQ:nYug48-VFa4:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:gIN9vFwOqvQ)
https://hameed.nwar.uk/vb//feeds.feedburner.com/~r/Medgadget/~4/MRfpCZ2oraQ
http://www.medgadget.com/wp-content/uploads/2015/03/blood-clot.jpgA 3-D rendering of fibrin forming a blood clot, with PolySTAT (in blue) binding strands together. William Walker/University of Washington
There are new*tech**logies (http://www.medgadget.com/2014/09/revmedx-gunshot-hemostasis-system-and-tourniquet-belt-at-tedmed-2014-video.html) out there that can help stop bleeding from gunshot wounds, a new approach may help deliver hemostasis on a microscopic scale. Researchers at the University of Washington have developed a new polymer that, when injected, rapidly works to help develop a solid clot.
The PolySTAT material works by fusing fibrin strands to each other and creating links between the clumps. This creates a strong web of fibrin capable of withstanding pressure from blood pressing against the clot. Importantly, the material is **t influenced by fibri**lytic enzymes that break up fibrin strands to begin the healing process. While the enzymes are important in the long run, they slow down clot formation, a dangerous activity during acute bleeding. Moreover, the material continues to work even when levels of a protein used to make fibrin drop.
In a pre-clinical study using lab rats, the researchers showed a 100% success rate in stopping bleeding to an otherwise lethal injury to the femoral artery. For*comparison, rats that were treated with albumin had only a 20% survival.
http://www.medgadget.com/wp-content/uploads/2015/03/fibrin-cross-linking.jpgBlood clots treated with PolySTAT (second from right) had denser fibrin networks, which helps reinforce and strengthen the clots. University of Washington
Study in Science Translational Medicine: A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis… (http://stm.sciencemag.org/content/7/277/277ra29)
Source: University of Washington… (http://www.washington.edu/news/2015/03/10/an-injectable-uw-polymer-could-keep-soldiers-trauma-patients-from-bleeding-to-death/)
The post Injectable Polymer Helps Stop Severe Bleeding (http://www.medgadget.com/2015/03/injectable-polymer-helps-stop-severe-bleeding.html) appeared first on Medgadget (http://www.medgadget.com).
http://feeds.feedburner.com/~ff/Medgadget?d=yIl2AUoC8zA (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:yIl2AUoC8zA) http://feeds.feedburner.com/~ff/Medgadget?d=qj6IDK7rITs (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:qj6IDK7rITs) http://feeds.feedburner.com/~ff/Medgadget?i=MRfpCZ2oraQ:nYug48-VFa4:gIN9vFwOqvQ (http://feeds.feedburner.com/~ff/Medgadget?a=MRfpCZ2oraQ:nYug48-VFa4:gIN9vFwOqvQ)
https://hameed.nwar.uk/vb//feeds.feedburner.com/~r/Medgadget/~4/MRfpCZ2oraQ