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02-24-2015, 12:40 AM
Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots
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Endovascular clot retrieval might become the standard future treatment for ischemic strokes, thanks to recent research published (http://www.nejm.org/doi/full/10.1056/NEJMoa1414792)in the New England Journal of Medicine. While this option may be better than existing clot busting *****, researchers at the*Houston Methodist Research Institute have developed new magnetic na**particles that can deliver a high concentration of a drug directly to the clot site, dissolving it orders of magnitude faster than direct injections.
The na**particles are made of iron oxide coated with albumin, which cloaks the na**particles so that the immune system does **t immediately target them. Because the particles are magnetic, they are readily seen under MRI and can be steered using an external magnetic guidance system. Moreover, the same magnet can induce a high frequency vibration of the na**particles, heating them up to further help with clot destruction.
The na**particles have so far been tested in a laboratory environment involving mice and human blood, while the cargo ferried was the commonly used thrombolytic tPA (tissue plasmi**gen activator).
From the study abstract in*Advanced Functional Materials:
In vitro, as compared to free tPA, the proposed na**constructs demonstrate a 100-fold increase in dissolution rate, possibly because of a more intimate interaction of tPA with the fibrin network. The clot dissolution rate is further enhanced (10-fold) by mild, localized heating resulting from the exposure of tPA–NCs to AMF. Intravital microscopy experiments demonstrate blood vessel reperfusion within a few minutes post tail vein injection of tPA–NCs. The proposed na**constructs also exhibit high transverse relaxivity (>400 × 10–3 m1 s1) for magnetic resonance imaging. The multifunctional properties and the 3 orders of magnitude enhancement in clot dissolution make tPA–NCs a promising na**-thera**sis agent in thrombotic disease.
Study in Advanced Functional Materials: TPA Immobilization on Iron Oxide Na**cubes and Localized Magnetic Hyperthermia Accelerate Blood Clot Lysis… (http://onlinelibrary.wiley.com/doi/10.1002/adfm.201404354/abstract)
Houston Methodist: Magnetic na**particles could stop blood clot-caused strokes… (http://www.eurekalert.org/pub_releases/2015-02/hm-mnc022315.php)
The post Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots (http://www.medgadget.com/2015/02/magnetic-na**particles-significatnly-speed-up-destruction-of-blood-clots.html) appeared first on Medgadget (http://www.medgadget.com).
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Endovascular clot retrieval might become the standard future treatment for ischemic strokes, thanks to recent research published (http://www.nejm.org/doi/full/10.1056/NEJMoa1414792)in the New England Journal of Medicine. While this option may be better than existing clot busting *****, researchers at the*Houston Methodist Research Institute have developed new magnetic na**particles that can deliver a high concentration of a drug directly to the clot site, dissolving it orders of magnitude faster than direct injections.
The na**particles are made of iron oxide coated with albumin, which cloaks the na**particles so that the immune system does **t immediately target them. Because the particles are magnetic, they are readily seen under MRI and can be steered using an external magnetic guidance system. Moreover, the same magnet can induce a high frequency vibration of the na**particles, heating them up to further help with clot destruction.
The na**particles have so far been tested in a laboratory environment involving mice and human blood, while the cargo ferried was the commonly used thrombolytic tPA (tissue plasmi**gen activator).
From the study abstract in*Advanced Functional Materials:
In vitro, as compared to free tPA, the proposed na**constructs demonstrate a 100-fold increase in dissolution rate, possibly because of a more intimate interaction of tPA with the fibrin network. The clot dissolution rate is further enhanced (10-fold) by mild, localized heating resulting from the exposure of tPA–NCs to AMF. Intravital microscopy experiments demonstrate blood vessel reperfusion within a few minutes post tail vein injection of tPA–NCs. The proposed na**constructs also exhibit high transverse relaxivity (>400 × 10–3 m1 s1) for magnetic resonance imaging. The multifunctional properties and the 3 orders of magnitude enhancement in clot dissolution make tPA–NCs a promising na**-thera**sis agent in thrombotic disease.
Study in Advanced Functional Materials: TPA Immobilization on Iron Oxide Na**cubes and Localized Magnetic Hyperthermia Accelerate Blood Clot Lysis… (http://onlinelibrary.wiley.com/doi/10.1002/adfm.201404354/abstract)
Houston Methodist: Magnetic na**particles could stop blood clot-caused strokes… (http://www.eurekalert.org/pub_releases/2015-02/hm-mnc022315.php)
The post Magnetic Na**particles Significatnly Speed Up Destruction of Blood Clots (http://www.medgadget.com/2015/02/magnetic-na**particles-significatnly-speed-up-destruction-of-blood-clots.html) appeared first on Medgadget (http://www.medgadget.com).
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